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A groundbreaking method for synthesizing diclofenac sodium was developed by Professor Chen Fenji from the Department of Chemistry at Fudan University. This innovative approach has revolutionized the traditional production process that has been in use globally for over three decades. The new technique significantly reduces environmental pollution and slashes raw material costs by nearly half, making it a game-changer in pharmaceutical manufacturing.
Diclofenac sodium, commonly known as diclofenac, is a widely used nonsteroidal anti-inflammatory drug (NSAID) effective for pain relief and reducing inflammation. It was first synthesized in Switzerland in 1966, and its industrial production using benzoic acid began in 1974. Since then, it has become one of the most popular medications worldwide, frequently prescribed for various conditions.
After more than a decade of research, Professor Chen Fenji introduced a novel synthesis method that starts with o-nitrotoluene and incorporates advanced techniques such as phase transfer catalysis, polymer-supported palladium catalytic reduction, condensation, and aromatization. Each step of the process achieves a yield of over 90%, with an overall yield exceeding 88%. This not only lowers production costs but also enhances product quality significantly.
As a result, major pharmaceutical producers in Switzerland, Japan, the U.S., and Germany have had to halt their own production and instead import the drug from China. The technology developed by Professor Chen has now been successfully scaled up in domestic pharmaceutical companies and has captured 80% of the global market share for this essential medication. This achievement marks a major milestone in China's pharmaceutical innovation and highlights the country's growing influence in the global healthcare industry.